Sedating and non sedating antihistamines
Histamine is stored in Antihistamines are medications that counteract the effect of the natural chemical histamine.
They are valuable drugs to reduce symptoms due to allergic diseases, especially those mediated by histamine.
Histamine affects nearby nerves resulting in itching.
That said, in overdose selectivity is lost and patients can develop increased sedation, anticholinergic effects and hypotension.
QT prolongation occurs secondary to potassium channel blockade.
Allergy season can be the worst time of year for people suffering with restless legs syndrome because popular over the counter medications can make symptoms much worse.
"Patients with restless legs syndrome already have difficulty sleeping as their symptoms tend to worsen at night or with rest, but sedating antihistamines, such as Benadryl, can intensify the symptoms," said William Ondo, M. Restless legs syndrome is considered a neurological and sleep disorder as patients feel uncomfortable sensations and strong urges to move their legs, which can sometimes be painful and often disrupts sleep.